Publications
Nanotechnologies: physicochemical characterisation, toxicology and risk assessment of nanomaterials
- Geiss O, Bianchi I, El Hadri ., Ponti J, Brassinne F, Wouters C, Mast J, Loeschner K, Givelet L, Cubadda F, Raggi A, Ferraris F, Gräf V, Devy Mantovan E, Zanella M., Benetti F., Barrero-Moreno J. Particle size analysis of iron hydroxide adipate tartrate (IHAT) in a supplement: Interlaboratory testing of a dynamic light scattering method. Journal of Food Composition and Analysis 2025; 137:106866
- Bianchi I, El Hadri H, Geiss O, Cheyns K, Mast J, Ferraris F, Cubadda F, El Hanafi K, Rosec J-P, Auger F, Barrero-Moreno J. A screening method for detection of TiO2 in food based on Raman spectroscopy and its applicability in a regulatory context. Food Control 2025; 168:110868
- Ferraris F, Adelantado C, Raggi A, Savini S, Zougagh M, Ríos Á, Cubadda F. An ICP-MS-based analytical strategy for assessing compliance with the ban of E 171 as a food additive on the EU market. Nanomaterials 2023;13(22):2597
- Ferraris F, Raggi A, Ponti J, Mehn D, Gilliland D, Savini S, Iacoponi F, Aureli F, Calzolai L, Cubadda F. Agglomeration behavior and fate of food-grade titanium dioxide in human gastrointestinal digestion and in the lysosomal environment. Nanomaterials. 2023;13(13):1908
- Schoonjans R, Castenmiller J, Chaudhry Q, Cubadda F, Daskaleros T, Franz R, Gott D, Mast J, Mortensen A, Oomen AG, Rauscher H, Weigel S, Astuto MC, Cattaneo I, Barthelemy E, Rincon A, Tarazona J. Regulatory safety assessment of nanoparticles for the food chain in Europe. Trends in Food Science & Technology. 2023;134:98-111
- Vincentini O, Prota V, Cecchetti S, Bertuccini L, Tinari A, Iosi F, De Angelis I. Towards the standardization of intestinal in vitro advanced barrier model for nanoparticles uptake and crossing: the SiO2 case study. Cells. 2022;11(21):3357
- Bianchi MG, Chiu M, Taurino G, Bergamaschi E, Cubadda F, Macaluso GM, Bussolati O. The TLR4/NFκB-dependent inflammatory response activated by LPS is inhibited in human macrophages pre-exposed to amorphous silica nanoparticles. Nanomaterials. 2022;12(13):2307
- Geiss O, Bianchi I, Bucher G, Verleysen E, Brassinne F, Mast J, Loeschner K, Givelet L, Cubadda F, Ferraris F, Raggi F, Iacoponi F, Peters R, Undas A, Müller A, Meinhardt A-K, Hetzer B, Gräf V, Montoro Bustos AR, Barrero J. Determination of the transport efficiency in spICP-MS analysis using conventional sample introduction systems: an interlaboratory comparison study. Nanomaterials. 2022;12(4):725
- Recordati C, De Maglie M, Cella C, Argentiere S, Paltrinieri S, Bianchessi S, Losa M, Fiordaliso F, Corbelli A, Milite G, Aureli F, D’Amato M, Raggi A, Cubadda F, Soldati S, Lenardi C, Scanziani E. Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system. Particle and Fibre Toxicology. 2021;18(23)
- Geiss O, Bianchi I, Senaldi C, Bucher G, Verleysen E, Waegeneers N, Brassinne F, Mast J, Loeschner K, Vidmar J, Aureli F, Cubadda F, Raggi A, Iacoponi F, Peters R, Müller A, Meinhardt A-K, Walz E, Gräf V, Barrero-Moreno J. Particle size analysis of pristine food-grade titanium dioxide and E 171 in confectionery products: Interlaboratory testing of a single-particle inductively coupled plasma mass spectrometry screening method and confirmation with transmission electron microscopy. Food Control. 2021;120:107550
- Schoonjans R, Cubadda F, Younes M. Chapter 12: The safety assessment of food chemicals in the nanoscale. In: Health and Environmental Safety of Nanomaterials, 2nd Edition (eds. Njuguna J, Pielichowski K and Zhu H.), Elsevier, Woodhead Publishing, Sawston, Cambridge, UK. 2021;291-303
- EFSA NDA Panel, Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Frenzel T, Heinonen M, Prieto Maradona M, Marchelli R, Neuhauser-Berthold M, Poulsen M, Schlatter JR, van Loveren H, Germini A, Knutsen HK. Safety of iron hydroxide adipate tartrate as a novel food pursuant to Regulation (EU) 2015/2283 and as a source of iron in the context of Directive 2002/46/EC. EFSA Journal. 2021;19(12):6935
- EFSA Scientific Committee, More S, Bampidis V, Benford D, Bragard C, Halldorsson T, Hernandez-Jerez A, Bennekou SH, Koutsoumanis K, Lambre C, Machera K, Naegeli H, Nielsen S, Schlatter J, Schrenk D, Silano V, Turck D, Younes M, Castenmiller J, Chaudhry Q, Cubadda F, Franz R, Gott D, Mast J, Mortensen A, Oomen AG, Weigel S, Barthelemy E, Rincon A, Tarazona J, Schoonjans R. Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles. EFSA Journal. 2021;19(8):6769
- EFSA Scientific Committee, More S, Bampidis V, Benford D, Bragard C, Halldorsson T, Hernandez-Jerez A, Hougaard Bennekou S, Koutsoumanis K, Lambre C, Machera K, Naegeli H, Nielsen S, Schlatter J, Schrenk D, Silano V, Turck D, Younes M, Castenmiller J, Chaudhry Q, Cubadda F, Franz R, Gott D, Mast J, Mortensen A, Oomen AG, Weigel S, Barthelemy E, Rincon A, Tarazona J, Schoonjans R. Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health. EFSA Journal 2021;19(8):6768
- Bianchi MG, Chiu M, Taurino G, Ruotolo R, Marmiroli N, Bergamaschi E, Cubadda F, Bussolati O. Pyrogenic and precipitated amorphous silica nanoparticles differentially affect cell responses to LPS in human macrophages. Nanomaterials. 2020;10(7):1395
- Aureli F, Ciprotti M, D’Amato M, do Nascimento da Silva E, Nisi S, Passeri D, Sorbo A, Raggi A, Rossi M, Cubadda F. Determination of total silicon and SiO2 particles using an ICP-MS based analytical platform for toxicokinetic studies of synthetic amorphous silica. Nanomaterials. 2020;10(5):888
- Boudard D, Aureli F, Laurent B, Sturm N, Raggi A, Antier E, Lakhdar L, Marche PN, Cottier M, Cubadda F, Bencsik A. Letter regarding “Chronic oral exposure to synthetic amorphous silica (NM-200) results in renal and liver lesions in mice”. The Authors Reply. Kidney International Reports. 2020;5(4):554-8
- Tassinari R, Di Felice G, Butteroni C, Barletta B, Corinti S, Cubadda F, Aureli F, Raggi A, Narciso L Tait S, Valeri M, Martinelli A, Di Virgilio A, Pacchierotti F, Cordelli E, Eleuteri P, Villani P, Fessard V, Maranghi F. Hazard identification of pyrogenic synthetic amorphous silica (NM-203) after sub-chronic oral exposure in rat: a multitarget approach. Food and Chemical Toxicology. 2020;137:111168
- Boudard D, Aureli F, Laurent B, Sturm N, Raggi A, Antier E, Lakhdar L, Marche PN, Cottier M, Cubadda F, Bencsik A. Chronic oral exposure to synthetic amorphous silica (NM-200) results in renal and liver lesions in mice. Kidney International Reports. 2019;4(10):1463-71
- Talamini L, Gimondi S, Violatto MB, Fiordaliso F, Pedica F, Tran LN, Sitia G, Aureli F, Raggi A, Nelissen I, Cubadda F, Bigini P, Diomede L. 2019. Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status. Nanotoxicology. 2019;13(8):1087-101
- Abraham K, Arcella D, Blume K, Boon PE, Brambilla G, Cubadda F, Dusemund B, Fabiansson S, Gürtler R, Heinemeyer G, Knüppel S, Lindtner O, Niemann B, Sieke C, Straßburg A. Exposure to Substances via Food Consumption. In: Heinemeyer G, Jantunen M, Hakkinen P. (ed.) The Practice of Consumer Exposure Assessment. Springer, Cham. 2019:167-359
- EFSA Scientific Committee, Hardy A, Benford D, Halldorsson T, Jeger MJ, Knutsen HK, More S, Naegeli H, Noteborn H, Ockleford C, Ricci A, Rychen G, Schlatter JR, Silano V, Solecki R, Turck D, Younes M, Chaudhry Q, Cubadda F, Gott D, Oomen A, Weigel S, Karamitrou M, Schoonjans R, Mortensen A. Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA Journal. 2018;16(7):5327
- Campagnolo L, Massimiani M, Vecchione L, Piccirilli D, Toschi N, Magrini A, Bonanno E, Scimeca M, Castagnozzi L, Buonanno G, Stabile L, Cubadda F, Aureli F, Fokkens PHB, Kreyling WG, Cassee FR, Pietroiusti A. Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus. Nanotoxicology. 2017;11(5):687-98
- Ammendolia MG, Iosi F, Maranghi F, Tassinari R, Cubadda F, Aureli F, Raggi A, Superti F, Mantovani A, De Berardis B. Short-term oral exposure to low doses of nano-sized TiO2 and potential modulatory effects on intestinal cells. Food and Chemical Toxicology. 2017;102:63-75
- Recordati C, De Maglie M, Bianchessi S, Argentiere S, Cella C, Mattiello S, Cubadda F, Aureli F, D’Amato M, Raggi A, Lenardi C, Milani P, Scanziani E. Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects. Particle and Fibre Toxicology. 2016;13:12
- Aureli F, D’Amato M, Raggi A, Cubadda F. Quantitative characterization of silica nanoparticles by asymmetric flow field flow fractionation coupled with online multiangle light scattering and ICP-MS/MS detection. Journal of Analytical Atomic Spectrometry. 2015;30(6):1266-73
- Gonzalez L, De Santis Puzzonia M, Ricci R, Aureli F, Guarguaglini G, Cubadda F, Leyns L, Cundari E, Kirsch-Volders M. Amorphous silica nanoparticles alter microtubule dynamics and cell migration. Nanotoxicology. 2015;9(6):729-36
- van Kesteren PCE, Cubadda F, Bouwmeester H, van Eijkeren JCH, Dekkers S, de Jong WH, Oomen AG. Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food. Nanotoxicology. 2015;9(4):442-52
- Rossi M, Cubadda F, Dini L, Terranova ML, Aureli F, Sorbo A, Passeri D. Scientific basis of nanotechnology, implications for the food sector and future trends. Trends in Food Science & Technology 2014;40(2):127-48
- Tassinari R, Cubadda F, Moracci G, Aureli F, D’Amato M, Valeri M, De Berardis B, Mantovani A, Passeri D, Rossi M, Maranghi F. Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology. 2014;8(6):654-62
- Schrand AM, Lin JB, Garrett CM, Brownheim SV, Hussain SM, Cubadda F, Nabiul Afrooz A R M, Saleh NB. Nanoparticle dynamics in the presence and absence of a cellular uptake altering chemical. Il Nuovo Cimento C. 2013; March-April(2):117-29
- Aureli F, D’Amato M, De Berardis B, Raggi A, Turco AC, Cubadda F. Investigating agglomeration and dissolution of silica nanoparticles in aqueous suspensions by dynamic reaction cell inductively coupled plasma-mass spectrometry in time resolved mode. Journal of Analytical Atomic Spectrometry. 2012;27(9):1540-8
