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MIAMOD and PIAMOD
Methods and software for estimating incidence and prevalence from population-based Cancer Registries data
Continuous monitoring of cancer burden indicators, such as mortality, incidence and prevalence, is important to evaluate progresses and define new cancer control programs. Usually only mortality data are systematically available from official statistics both at local and national scale. Incidence data are collected by population based Cancer Registries and, with some exceptions, they cover only a fraction of the national population. MIAMOD and PIAMOD are statistical methods, developed by researchers from the Istituto Superiore di Sanità (National Institute of Health, Rome, Italy) to estimate and project cancer incidence and prevalence both at regional and national level.

MIAMOD method
The MIAMOD method (Mortality and Incidence Analysis MODel) has been first proposed.
It involves modelling incidence as an age, period and cohort (APC) function and back-calculating its parameters from cancer mortality and survival. Both observed data and model-based survival estimates can be used. Based on APC estimated parameters, incidence is projected into past and future years. Prevalence is derived from estimated and projected incidence by convolution of cancer incidence and survival over time. In the last fifteen years several papers presenting MIAMOD applications to the most relevant cancer sites (breast, lung, colorectal, stomach, cervix uteri, skin melanoma, prostate) were published.

PIAMOD method
The PIAMOD method (Prevalence and Incidence Analysis MODel) is an alternative to MIAMOD for estimating and projecting prevalence when incidence data are available, i.e. on the areas covered by cancer registration. In PIAMOD observed incidence is directly modelled as an APC model. Prevalence is derived, as in MIAMOD method, from the convolution of cancer incidence and survival over time.

MIAMOD/PIAMOD software
Both methods are available in a software ad hoc developed in consultation with the Surveillance Research Program of the Division of Cancer and Population Sciences (National Cancer Institute, Bethesda USA). The software is distributed free of charge and provides a user-friendly interface to run both MIAMOD and PIAMOD programs on PC workstations under Windows Operating Systems. To receive a copy of MIAMOD/PIAMOD software please contact the following address: roberta.deangelis@iss.it

Courses on MIAMOD/PIAMOD methods software
The introductory course on MIAMOD/PIAMOD software is addressed to epidemiologist and statisticians dealing with population-based Cancer Registries data. The aims of the course are:

  • to give a general overview of the statistical methods for estimating cancer morbidity implemented by the MIAMOD/PIAMOD software
  • to introduce methods and programs for cancer survival modelling 
  • to enable participants to produce incidence and prevalence estimates by using the MIAMOD/PIAMOD software

The past editions of the course were held in:

  • 2009 Tehran (Iran) Cancer Research Center, 25-27 April 2009 (Program 2009)
  • 2008 Rome (Italy), Istituto Superiore di Sanità, 26-28 November (Brochure Rome 2008)
  • 2008 Granada (Spain), Esculea Andaluza de Salud Publica, 24-26 September (Brochure Granada 2008)
  • 2007 Rome (Italy), Istituto Superiore di Sanità, March 7-9 2007 (Program 2007)
  • 2006 Locarno (Switzerland), Registro Tumori del Canton Ticino, March 8-10 (Program 2006)
  • 2005 Rome (Italy), Istituto Superiore di Sanità, October 19-21 (Program 2005)

Contacting the authors
All correspondence concerning the software should be addressed to :

Dr. Roberta De Angelis
Istituto Superiore di Sanità
Centro Nazionale di Epidemiologia Sorveglianza e Promozione della Salute
Viale Regina Elena 299, 00161 Roma
Tel. +39.06.49904289
Fax +39.06.49904285
e-mail: roberta.deangelis@iss

REFERENCES:

MIAMOD method 

  • Verdecchia A., Capocaccia R., Egidi V., and Golini A. A Method for the Estimation of Chronic Disease Morbidity and Trends From Mortality Data. Statistics in Medicine 1989;8(2):201-16 
  • Capocaccia R. Estimation of morbidity from chronic disease mortality. Morgenstern W., Chigan E., Prokhorskas R., Rusnak M., and Schettler G. Models of noncommunicable diseases.Springer - Verlag; 1992. pp.33-44
  • Capocaccia R. Relationships Between Incidence and Mortality in Non-Reversible Diseases
  • Statistics in Medicine 1993;12:2395-415 

MIAMOD software 

  • De Angelis G., De Angelis R., Frova L., and Verdecchia A. Miamod: a Computer Package to Estimate Chronic Disease Morbidity Using Mortality and Survival Data. Computer methods and programs in biomedicine 1994;44(2):99-107 

PIAMOD method 

  • Verdecchia A., De Angelis G., and Capocaccia R. Estimation and Projections of Cancer Prevalence From Cancer Registry Data. Statistics in Medicine 2002;21:3511-26

APPLICATIONS 

  • Budroni M., Sechi O., Cossu A., Palmieri G., Tanda F., Foschi R. et al.: Estimates of cancer burden in Sardinia. Tumori 2013, 99: 408-415. 
  • Falcini F., Mancini S., Ravaioli A., Vattiato R., Bucchi L., Rossi S. et al.: Estimates of cancer burden in Emilia-Romagna. Tumori 2013, 99: 327-333
  • Foschi R., Viviano L., Rossi S.: Estimates of cancer burden in Abruzzo and Molise. Tumori 2013, 99: 366-373
  • Fusco M., De Angelis R., Senatore G., Zigon G., Rossi S.: Estimates of cancer burden in Campania. Tumori 2013, 99: 374-381 
  • Galasso R., Capocaccia R., Del Riccio L., Viviano L., Matera R., Rossi S.: Estimates of cancer burden in Basilicata and Calabria. Tumori 2013, 99: 390-389 
  • Galise I., Rashid I., Bisceglia L., Coviello V., Melcarne A., Sante M. et al.: Estimates of cancer burden in Puglia. Tumori 2013, 99: 382-389  
  • Gatta G., Ciampichini R., Bisanti L., Contiero P., Tessandori R., Baili P. et al.: Estimates of cancer burden in lombardy. Tumori 2013, 99: 277-284 
  • Piffer S., Gentilini M., Rizzello R., Mazzoleni G., Bellù F., Rossi S.: Estimates of cancer burden in Trentino-Alto Adige. Tumori 2013, 99: 296-307   
  • Rashid I., Pannozzo F., Rossi S., Foschi R.: Estimates of cancer burden in Lazio. Tumori 2013, 99: 359-365 
  • Rossi S., Crocetti E., Capocaccia R., Gatta G., AIRTUM Working Group: Estimates of cancer burden in Italy. Tumori 2013, 99: 416-424  
  • Rosso S., Sacchetto L., Giacomin A., Foschi R., De Angelis R., Rossi S. et al.: Estimates of cancer burden in Piedmont and Aosta Valley. Tumori 2013, 99: 269-276  
  • Stracci F., Saba Petrucci M., Ciampichini R., Tavilla A., Foschi R.: Estimates of cancer burden in Umbria. Tumori 2013, 99: 342-350
  • Tavilla A., Vitarelli S., Rossi S., Foschi R.: Estimates of cancer burden in Marche. Tumori 2013, 99: 351-358
  • Tognazzo S., De Angelis R., Ciampichini R., Gatta G.: Estimates of cancer burden in Veneto. Tumori 2013, 99: 308-317
  • Tumino R., Capocaccia R., Traina A., Madeddu A., Contrino M.L., Zigon G.: Estimates of cancer burden in Sicily. Tumori 2013, 99: 399-407 
  • Vercelli M., Quaglia A., Lillini R., Rossi S., Foschi R., Registro Tumori Regione Liguria: Estimates of cancer burden in Liguria. Tumori 2013, 99: 285-295 
  • Vercelli M., Quaglia A., Lillini R.: Useful indicators to nterpret the cancer burden in Italy. Tumori 2013, 99: 425-438
  • Zucchetto A., Serraino D., Dal Maso L., Birri S., Francisci S., Zigon G. et al.: Cancer estimates up to 2015 in Friuli Venezia Giulia. Tumori 2013, 99: 318-326 
  • AIRTUM Working Group, Capocaccia R., Crocetti E., De Angelis R., Ferretti S., Gatta G. et al.. I tumori in Italia, rapporto 2007: Sopravvivenza. [1 supplemento 1], 1-95. 2007.  Rivista dell'associazione italiana di epidemiologia. Epidemiologia & Prevenzione
  • Baili P., De Angelis R., Casella C., Grande E., Inghelmann R., Francisci S. et al.: Italian cancer burden by broad geographical area. Tumori 2007, 93: 398-407
  • Capocaccia R., Buzzoni C., Grande E., Inghelmann R., Bellù F., Cassetti T. et al.: Estimated and observed cancer incidence in Italy: a validation study. Tumori 2007, 93: 387-391
  • De Angelis R., Grande E., Inghelmann R., Francisci S., Micheli A., Baili P. et al.: Cancer prevalence estimates in Italy from 1970 to 2010. Tumori 2007, 93: 392-397 
  • Grande E., Inghelmann R., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of breast cancer burden in Italy. Tumori 2007, 93: 374-379
  • Grande E., Inghelmann R., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of colorectal cancer burden in Italy. Tumori 2007, 93: 352-359 
  • Grande E., Inghelmann R., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of all cancer malignancies in Italy. Tumori 2007, 93: 345-351 
  • Inghelmann R., Grande E., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of prostate cancer burden in Italy. Tumori 2007, 93: 380-386 
  • Inghelmann R., Grande E., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of stomach cancer burden in Italy. Tumori 2007, 93: 367-373 
  • Inghelmann R., Grande E., Francisci S., Verdecchia A., Micheli A., Baili P. et al.: Regional estimates of lung cancer burden in Italy. Tumori 2007, 93: 360-366
  • Micheli A., Berrino F., Paci E., Verdecchia A., Pierotti M.A.: Strategies for cancer control in Italy. Tumori 2007, 93: 329-336 
  • Verdecchia A., De Angelis R., Francisci S., Grande E.: Methodology for estimation of cancer incidence, survival and prevalence in italian regions. Tumori 2007, 93: 337-344 
  • A. Mariotto, K. Yabroff, E. Feuer, R. De Angelis, M. Brown, Projecting the number of patients with colorectal carcinoma by phases of care in the US: 2000-2020, Cancer Causes Control, 17, 2006: 1215-1226 
  • E.Grande, R. Inghelmann, S. Francisci, A. Verdecchia, A. Micheli, R.Capocaccia, R. De Angelis, Estimating regional cancer burden in countries with partial registration coverage: An application to all malignant neoplasms in Italy over the period 1970-2010, European Journal of Cancer, 42, 2006, pp.3236-3245 
  • Verdecchia A., Mariotto A., Capocaccia R., Gatta G., Micheli A., Sant M., and Berrino F. Incidence and Prevalence of All Cancerous Diseases in Italy: Trends and Implications. European Journal of Cancer 2001;37(9):1149-57 
  • Mariotto A., Dally L.G., Micheli A., Canario F., and Verdecchia A. Cancer Prevalence in Italian Regions With Local Cancer Registries. Tumori 1999;85:400-7
  • De Angelis R., Valente F., Frova L., Verdecchia A., Gatta G., Chessa E., and Berrino F. Trends of Colorectal Cancer Incidence and Prevalence in Italian Regions. Tumori 1998;84:1-8 
  • Capocaccia R., De Angelis R., Frova L., Gatta G., Sant M., Micheli A., Berrino F., Conti E., Gafà L., Roncucci L., and Verdecchia A. Estimation and Projections of Colorectal Cancer Trends in Italy. International Journal of Epidemiology 1997;26:924-32 
  • De Angelis R., Valente F., Frova L., Capocaccia R., Micheli A., Chessa E., and Sant M. Incidence, Mortality and Prevalence of Stomach Cancer in Italian Regions. Tumori 1996;82:314-20
  • Capocaccia R., De Angelis R., Frova L., Sant M., Buiatti E., Gatta G., Micheli A., Berrino F., Barchielli A., Conti E., Gafà L., and Verdecchia A. Estimation and Projections of Stomach Cancer Trends in Italy. Cancer Causes and Control 1995;6:339-46 
  • Capocaccia R., Micheli A., Berrino F., Gatta G., Sant M., Ruzza M.R., Valente F., and Verdecchia A. Time Trends of Lung and Larynx Cancers in Italy. International Journal of Cancer 1994;57(2):154-61 
  • Micheli A., Verdecchia A., Capocaccia R., De Angelis G., Gatta G., Sant M., Valente F., and Berrino F. Estimated Incidence and Prevalence of Female Breast Cancer in Italian Regions. Tumori 1992;78:13-21   
  • Capocaccia R., Verdecchia A., Micheli A., Sant M., Gatta G., and Berrino F. Breast Cancer Incidence and Prevalence Estimated From Survival and Mortality. Cancer Causes and Control 1990;1:23-9  

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